14 datasets found

Proteins are the workhorses of the cell, performing a huge array of functions from providing mechanical strength to molecular recognition & binding. They perform these...

This proposal forms part of an ongoing project concerning interpenetrating network gels of starch and cellulose being developed towards applications in personal care and...

Hydrogels are formed by the self-assembly of cross-linked building blocks in water.By using a folded protein as the building block, we wish to harness the intrinsic and specific...

In our recent research at King’s we have shown that significant increases in micellar drug solubilization can be achieved by ‘matching' the hydrophobe of a drug with the...

The genetic code of viruses is typically protected by a spherical protein container. This protein capsid is assembled from hundreds of individual proteins in a spontaneous...

Aqueous creams are widely used in the treatment of skin conditions like rosacea, dermatitis and psoriasis. They are highly complex chemical mixtures, and our knowledge of their...

Layered double hydroxides (LDHs) have recently been identified as interesting drug delivery vehicles due to their ability to intercalate guest molecules. Additionally, LDHs...

G-quadruplexes (G4) are the focus of a number of studies in both fundamental and applied research, from cancer biology and novel therapeutics through to nanotechnology. The G4...

In collaboration with Infineum (a world-leading engine-oil additive company), we propose a SANS study of self-assembly of novel polymethacrylate (PMA) block copolymers as a...

Polymers with a very balanced hydrophilicity can translocate through biological membranes without doing damage. This simulates natural metabolism, and, therefore, allow for...

We are investigating a range of functionalised dipeptides. For some examples, anisotropic structures are formed in water at high pH, which can be gelled by addition of a calcium...

At high pH many low molecular weight gelators (LMWG) are dispersed in solution. When a trigger is applied to lower the pH the gelator molecules self-assemble into one...

Human dihydroorotate dehydrogenase (DHODH) is an integral membrane protein found in mitochondria involved in the biosynthesis of pyrimidines. DHODH oxidizes dihydroorotate with...

Bowel cancer is the fourth most common cancer in the UK with approximately 41,000 individuals in the UK diagnosed annually. Importantly it is estimated that over half of all...