Layered double hydroxides (LDHs) have recently been identified as interesting drug delivery vehicles due to their ability to intercalate guest molecules. Additionally, LDHs display membrane-disrupting capabilities and antimicrobial effects on their own. However, understanding the relation between membrane interactions and antimicrobial effects is critical for the successful use of LDH as antimicrobial agents and as carriers of guest molecules such as antimicrobial peptides. In order to elucidate the membrane disruption mechanism of LDHs, we propose to investigate the effect of particle size by using three LDH particles with differing aspect ratios (42, 104, and 208 nm). Each particle will be measured with both bacteria-mimicking and mammalian-mimicking lipid membranes that have been contrast matched to D2O such that the only small angle scattering will be from the LDH particles.