In our recent research at King’s we have shown that significant increases in micellar drug solubilization can be achieved by ‘matching' the hydrophobe of a drug with the hydrophobe of the surfactant. We have shown proof-of-principle by means of solubilization studies carried out for ibuprofen and indomethacin using the surfactant Triton-X-100 - which has a hydrophobe similar to ibuprofen and dissimilar to that of indomethacin. We subsequently hypothesized that sodium 4-isobutylbenzene sulfonate - which has a hydrophobe even more closely matched to that of ibuprofen - would exhibit even better drug solubilzation, and showed that this was indeed the case.SANS studies of these systems are proposed to determine the structure of the micellar aggregates of sodium 4-isobutylbenzene sulfonate (4IBS) and the structure of these micelles with incorporated ibuprofen and indomethacin.