Nanoarchitecture of folded maltose binding protein hydrogels

DOI

Proteins are the workhorses of the cell, performing a huge array of functions from providing mechanical strength to molecular recognition & binding. They perform these functions due to their specific, well-defined and evolutionary optimized folded structures. We are interested in their potential as building blocks for functional biomaterials. Our goal is to develop a cross-lengthscale understanding of the physics of folded protein networks, specifically in chemically cross-linked protein hydrogels. SANS measurements will provide essential information on the structure of our gels, and will be vital in bridging the structural/mechanical information from computational modelling to the mechanical insight from rheological measurements. This study will deliver (i) crucial benchmarking of our simulations (ii) structural information to guide our future applications of these novel biomaterials.

Identifier
DOI https://doi.org/10.5286/ISIS.E.98002310
Metadata Access https://icatisis.esc.rl.ac.uk/oaipmh/request?verb=GetRecord&metadataPrefix=oai_datacite&identifier=oai:icatisis.esc.rl.ac.uk:inv/98002310
Provenance
Creator Dr Matthew Hughes; Professor Lorna Dougan; Dr Najet Mahmoudi; Miss Sophie Cussons; Dr Harrison Laurent
Publisher ISIS Neutron and Muon Source
Publication Year 2021
Rights CC-BY Attribution 4.0 International; https://creativecommons.org/licenses/by/4.0/
OpenAccess true
Contact isisdata(at)stfc.ac.uk
Representation
Resource Type Dataset
Discipline Biology; Biomaterials; Engineering Sciences; Life Sciences; Materials Science; Materials Science and Engineering; Medicine; Natural Sciences; Physics
Temporal Coverage Begin 2018-10-02T08:00:00Z
Temporal Coverage End 2018-10-06T08:54:19Z