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SANS Studies of Novel Internally Stabilised Liposomes
Internally supported liposomes (ISLs) are composed of polymeric spheres enclosed by liposomes. Although very little research has been done on ISLs, understanding their... -
On the structure and composition of non-lamellar lipid-based liquid crystalli...
To better understand the properties of non-lamellar liquid crystalline nanoparticles (LCNP) as delivery vehicles, it is crucial to understand their internal structure and the... -
How do polymeric de-emulsifiers work? Contrast variation studies with model w...
The project is to understand fundamental structure-performance relationships of chemical demulsifiers in water-in-crude oil (w/o) systems. In particular, to understand how... -
Structural development of magnetite chains
One dimensional (1D) magnetic nanostructures exhibit anisotropic magnetic properties and thereby differ from unstructured materials. However, magnetic chains are energetically... -
Impact of homo- and hetero-association of complex molecular nano-sized drug d...
The present proposal concerns a PEGylated, hydrophobic drug containing polylysine dendrimer that demonstrates unexplained batch-to-batch variability in that two batches of the... -
Optimizing micellar drug solubilisation using surfactant designed with a hydr...
In our recent research at Kings we have shown that significant increases in micellar drug solubilization can be achieved by matching' the hydrophobe of a drug with the... -
Protein-decorated superparamagnetic iron oxide nanoparticles
The aim of this research is to understand the structural confirmation of dextran coated iron oxide (Fe3O4) nanoparticles in the presence of Bovine serum albumin (BSA) in aqueous... -
Investigating Mesoporosity in Hierarchical Aluminophosphates
Optimising catalyst lifetime and performance is pivotal to enhancing the sustainability of industrial catalytic processes, allowing greater product yields, at lower... -
Mechanism and rates of phospholipid exchange and flip-flop under physiologica...
Variation in lipid composition between different biological membrane and across membranes are vital for a wide range of cellular functions. Significant differences in lipid... -
The solution structure of E.coli peripheral membrane protein FtsA solubilised...
We will measure the solution structure of a protein complex from bacteria essential for cell division. The two proteins, FtsA and FtsZ, are known to interact with each other... -
Probing mucoadhesive interactions between porcine gastric mucin and water-sol...
Mucoadhesion is the ability of polymers to adhere to mucosal membranes in the human body and provide a temporary retention. It has been widely used to develop polymeric dosage... -
Studies of the mechanism of hydrotropy
The objective is to refine current understanding about the mechanism of hydrotropy with respect to polarity and electrostatic character of hydrotropes and hydrophobic solutes... -
Interaction of keratin with surfactants studied by SANS
This proposal constitutes part of our ongoing study towards understanding how keratin, an important protein component of hair and skin, interacts with ionic surfactants using... -
Measuring phospholipid flip-flop rates across vesicle bilayers
Asymmetry across biological membranes is vital for a wide range of organelle and cellular functions. Significant differences in lipid composition have been found between the... -
Increasing Drug Solubilisation: Matching Drug Structure with Surfactant Hydro...
It is estimated that > 40% of new drug molecules are poorly water soluble. For many reasons, solubilisation in nonionic surfactant micelles is a favoured means of increasing... -
Using contrast matching to understand the networks in multicomponent systems
We have been focusing on two component gel networks. Here, both components can individually form gels. In a mixed system, the LMWG can either co-assemble or self-sort. In a... -
Co-adsorption of eggshell membrane polypeptide-surfactant mixtures at oil-in-...
An eggshell membrane polypeptide is highly surface active and effective at emulsion stabilization. We explore how to use SANS to study the interfacial layers surrounding the... -
Structure of siRNA containing delivery vehicles: effect of serum
Complexes prepared from cationic, dichain lipid (L) vesicles and negatively charged siRNA (R), with and without positively chargely targeting peptides (P) known as LR or LPR... -
SANS DLS Commissioning
This dataset has no description
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Reconstituted lipoprotein particles - Implications of structure and dynamics ...
Neutron scattering will allow to advance the understanding of lipoprotein behavior in solution and at the interface of relevant biological interfaces. Here we focus on HDL...
