The global COVID-19 spread has forced countries to implement non-pharmacological interventions (NPI) to preserve health systems. Spain is one of the most severely impacted countries, both clinically and economically. In an effort to support policy decision-making, Candel et al.(2021) [https://dx.doi.org/10.2139/ssrn.3745801] have developed a modified Susceptible-Exposed-Infectious-Removed (SEIR) epidemiological model to simulate the pandemic evolution. Its output was used to populate an economic model to quantify healthcare costs and GDP variation, through a regression model which correlates NPI and GDP change from 42 countries. The dataset contains information on the main variables used in order to specify and estimate this predictive model.