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Structure of a bacterial membrane chaperone complex
The proteins of the outer membrane of Gram-negative bacteria are critical for bacterial survival. The understanding of how these proteins are targeted and folded into this... -
Temperature Effects and Kinetics of Thiolipid Adsorption to Gold Surfaces
We have a programme investigating the structure and function of protein scaffolds oriented on gold surfaces using sulfur chemistry for attachment. The aim is to direct the... -
Inelastic neutron scattering spectra of hydrogen absorbed in palladium-silver...
Pd-Ag alloys find technological applications in H uptake and purification. Among various peculiar properties, their electric resistivity variation as a function of the H loading... -
Understanding the insertion of antibiotic toxins into the gram negative outer...
The gram-negative bacterial membrane is of extreme medical importance. Two of its major components are lipopolysaccharides (LPS's) and integral membrane proteins. Porins are... -
Effect of membrane fluidity for novel dendrimer drug interaction and uptake m...
Bacteria growing resistant to common antibiotics is a growing problem and research in new types of medicines which do not induce resistance is therefore very important. Novel... -
Outer membrane mimics using novel thiol-PC
We have recently shown that dense monolayers of PC can be assembled on gold surfaces using a new omega thiol PC from Avanti. This has two advantages over our previous methods.... -
Probing the effects of oxidative stress on the membrane binding of alpha-synu...
Neutron reflectometry will be used to characterise the cellular membrane binding interaction of alpha-synuclein under conditions mimicking oxidative stress. Alpha-synuclein is... -
Probing membrane localisation of molecular rotors (NR)
A number of important biological processes, such as intracellular transport and signal transduction depend on the viscosity and the distribution of microdomains in cells. We... -
Protein secretion: Studying the folding and assembly of membrane proteins usi...
This dataset has no description
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Characterisation and peptide resistance capabilities of bacterial membrane mi...
Lysylphosphatidylglycerol (LPG) is a major constituent of the plasma membrane of the bacterial pathogen methicilin resistant Staphylococcus aureus (MRSA), which has been... -
Conformational analysis of subtilin / lipid II binary antibiotic/target membr...
We propose to use neutron reflection to characterise the position and shape of subtilin/lipid II pore complexes as well as to characterise the kinetics of subtilin-lipid II and... -
Oriented antibody binding layers
The proposal concerns the assembly of high density antibody binding surfaces to increase the sensitivity of medical diagnostics. Previously we showed that antibody binding... -
More realistic models of the bacterial outer membrane
Current model systems employed in structural studies of bacterial outer membranes rarely mimic the lipid composition accurately. This work is aimed at producing outer membrane... -
SANS studies of phospholipid:sterol vesicles and the membrane interactions of...
The increasing incidence of pathogenic fungi resistant to treatment with amphotericin B (AmB) has created a demand for novel anti-fungal agents that can circumvent the... -
Organisation of Outer membrane protein F at the air/liquid interface
Crystallisation of membrane proteins as a precursor to high resolution structural studies is a significant research bottleneck. We are investigating alternative methods to... -
The influence of transmembrane potential on the orientation of antimicrobial ...
Natural antimicrobials are of great interest, since they are antibiotics that act on the biological membrane, and it is believed that this makes it far more difficult for... -
Conformational analysis of subtilin / lipid II binary antibiotic/target membr...
Antibiotic resistance is pathogenic bacteria is a major clinical problem. Resistance to all antibiotiotic classes, currentl yin clinical use, has been reported. By contrast, the... -
Planar bilayer formation on novel cationic surface suitable for membrane prot...
Membrane receptor proteins (MRPs) which are thought to represent the majority of drug targets are challenging to study as their structure and function is dependent on being... -
Effect of membrane fluidity for novel dendrimer drug interaction and uptake m...
Bacteria growing resistant to common antibiotics is a growing problem and research in new types of medicines which do not induce resistance is therefore very important. Novel...
