-
Comparing the assembly of LPS into model Outer Membranes by Langmuir-Blodgett...
We have recently created and published a model of the Gram negative bacterial Outer membrane (OM) which recreates many aspects of its behaviour and will improve our ability to... -
Comparative Interaction Studies of Antimicrobial Agents on Floating Asymmetri...
The outer membrane (OM) of Gram-Negative bacteria (GNB) is an asymmetric structure which contains complex lipids known as lipopolysaccharides (LPSs) on the outer surface. LPSs... -
A complex model of the bacterial outer membrane containing oriented proteins ...
The Outer Membrane (OM) is found in bacteria which cause plague, cholera & Legionnaire¿s disease. It is important as; a barrier to antibiotics & the site of... -
Mimicking Pathogens : Floating Gram Negative Bacterial Membranes Containing t...
Recently we have been able to show two advances in the creation of realistic models of the Gram negative bacterial outer surface for use in biophysical and structural studies.... -
The structure and orientation of the Bam complex in the Gram-negative outer m...
The proteins of the outer membrane of Gram-negative bacteria are critical for bacterialsurvival, from providing basic physiological functions, to aiding virulence and... -
Orientation of an Antimicrobial Peptide in Eukaryotic and Prokaryotic Membranes.
Antimicrobial peptides are small, usually alpha-helical peptides that kill cells by disrupting the cell membrane. Recently, we have been studying a simple 'designed'... -
Antibiotic paths through the bacterial outer membrane: The strange case of va...
Gram-negative bacteria, which cause a variety of diseases including meningitis, plague, sepsis and food poisoning, are becoming increasingly antibiotic resistant. One reason is... -
Direct Observation of Gram Negative Bacterial Membrane Disruption by Supramol...
Cyclic peptides with alternating side chain stereochemistry are capable of self-assembling into long nanotubes. The conjugation of polymers to these peptides renders the... -
New Approaches to Producing Floating Supported Bilayers
The complex sample environment needed for floating supported bilayers has often led to a need to constantly redevelop the system to improve reproducibility. Here we plan to... -
The mechanism of lipid transport in Gram-negative bacteria
The bacterial cell envelope is one of the best targets in antimicrobial development. This proposal focuses on understanding how lipids move between the membranes of the... -
Benchmarking improvements in experimental design in neutron reflectometry
This dataset has no description
-
Luke Clifton Sample commissioning
This dataset has no description
-
NR Study of Selective Binding of a-Helix Antimicrobial Peptides onto Bacteria...
In this work we will explore how to use PolRef to study the binding of our rationally designed peptide amphiphiles onto floating lipid bilayers mimicking G- bacterial and red... -
Comparative Interaction Studies of Antimicrobial Agents on Floating Asymmetri...
The outer membrane (OM) of Gram-Negative bacteria (GNB) is an asymmetric structure which contains complex lipids known as lipopolysaccharides (LPSs) on the outer surface. LPSs... -
A complex model of the bacterial outer membrane containing oriented proteins ...
The Outer Membrane (OM) is found in bacteria which cause plague, cholera & Legionnaire?s disease. It is important as; a barrier to antibiotics & the site of... -
The Interaction of Small Cationic Amphiphillic Antimicrobial Proteins with Fr...
Protein-membranes interactions are fundamentally important to biological function. We have developed advanced models of the Gram negative bacterial outer membrane and have... -
Assembling Biomimetic layers on monolayers of Gold Nanoparticles
Gold provides a high quality surface on which to arrange biomolecules such as proteins since we can use cysteine amino acids to deliver gold thiol chemical bonds which can... -
A comparative NR study of interaction of short designed antimicrobial peptide...
The global increase of bacterial resistance to antibiotics has led to increasing interest in research focusing on the development and characterization of new antimicrobial... -
Self-assembled Floating Lipid Bilayers: What Forces Are Causing the Bilayer t...
Recently (RB19100102) we have discovered that floating bilayers composed of fluid phase lipids can be produced by deposited vesicles onto charge modified oligo(ethylene... -
Recreating the specific colicin NRa-LPS interaction in a model bacterial out...
The Gram negative bacterial outer membrane protects the bacterium from external toxins such as antibiotics. This is partially responsible for Gram negative bacteria becoming the...
