Gold provides a high quality surface on which to arrange biomolecules such as proteins since we can use cysteine amino acids to deliver gold thiol chemical bonds which can orient the proteins in a defined manner. Whilst a thin layer of gold can be produced by sputtering this is opaque and limits the use of these surfaces in microscopy which is a major component of biological analysis. In collaboration with Orla Protein Technologies Ltd we are studying glass slides upon which a layer of gold nanoparticles has been assembled. Biomolecules can be assembled on these layers which are being measured by a range of technique including electron microscopy, XPS and AFM but only neutron reflectivity can image and provide a profile of the density and distribution of all the components. We hope to use neutron reflectivity in conjunction with QCM-D which can measure the mass increases directly.