49 datasets found

Hospital-acquired infections of medical devices result in approximately 100,000 deaths each year in the US alone, it is therefore a priority to tackle this. To this end, we have...

Conjugation of therapeutic proteins to polymers is well established but most methods result in multi-site and multiple conjugation or crosslinking resulting in lack of...

It is proposed to use time-resolved SANS (TR-SANS) to elucidate growth kinetics of composite latex-silica core-shell particles. These core-shell particles form the basis...

As part of a larger programme we aim to test densely-packed binary mixtures of monodisperse hard sphere powders to determine local structure, to correlate with ratio of...

Conjugation of therapeutic proteins to polymers is well established but most methods result in multi-site and multiple conjugation, crosslinking resulting in lack of orientation...

CO2 foams can be formed in water/carbon dioxide (W/CO2) mixtures with the aid of W/CO2 interfacially active hydrocarbon surfactants and surface treated silica nanoparticles...

Nanodiscs are self-assembled structures composed of phospholipids stabilised by a polymer belt. They are capable of encapsulating single membrane proteins and as such have many...

This proposal explores headgroup-free, fluorocarbon-hydrocarbon hybrid compounds able toform viscous elongated aggregates in supercritical CO2 with the aim of improving...

Our group has been working partially oxidized cellulose nanofibrils which form gels in aqueous formulations. Recently we have observed that these fibrils also gel when dialysed...

Polymer stabilized lipid nanodiscs offer enormous potential as tools for enabling membrane protein structural studies and biophysics. Previously we have studied nanodisc...

Nanodiscs are self-assembled structures composed of phospholipids containing a stabilizing membrane-scaffold protein or, in the case of this proposal, a polymer belt. They are...

Deep Eutectic Solvents (DES) are molecular mixtures similar to ionic liquids, having melting points below room temperature. However instead of being composed of a salt, the...

Nanostructured lipid aggregates offer enormous potential as tools for membrane structural biology and biophysics. Poly(Styrene-Maleic Acid) stabilized lipid nanodiscs can be...

The crystallisation of membrane proteins is of great interest, not least, to the pharmaceutical industry. We have recently begun a project aiming to investigate the role played...

This proposal continues our research on ion binding to surfactant micelles. Our recent work demonstrates that the details of water structure around micelles are now accessible...

An analogue of the popular surfactant AOT with isopropyl glycol tails (IG-AOT, Figure.1) has been recently designed as a co-surfactant for water-in-CO2 (w/c) systems: stable...

We propose a study to extend the understanding of the influence of salt on the structure of DPPG membranes floating on an al-PC bilayer. We have previously demonstrated the...

Deep Eutectic Solvents (DES) are molecular mixtures similar to ionic liquids, having melting points below room temperature. However instead of being composed of a salt, the...

In recent work with Unilever we have been investigating the structure of gels formed by partially oxidised cellulose nanofibrils for use in sustainable personal care products....

This proposal explores headgroup-free, fluorocarbon-hydrocarbon hybrid compounds able toform viscous elongated aggregates in supercritical CO2 with the aim of improving...