Assessing a potential method to form kinetically trapped, self-assembling nanotubes

DOI

Cyclic peptide-polymer conjugates can readily self-assembly into long nanotubes, and are being extensively studied for drug delivery applications. Recently, using SANS and fluorescence techniques we were able to show the dynamic nature of the self-assembly process. As such, our research focus has shifted to make kinetically trapped systems. This has been achieved using hydrophobic/hydrophilic diblock co-polymers, and characterized using XPRESS SANS time and light scattering. In the proposed experiment, we will look at different structural parameters and preparation methods to hone in on the ideal parameters needed to make tubes of a controlled length. Controlling the assembly and size of the nanotubes is of great importance, given the range in biomedical applications for these novel systems.

Identifier
DOI https://doi.org/10.5286/ISIS.E.RB1820150-1
Metadata Access https://icatisis.esc.rl.ac.uk/oaipmh/request?verb=GetRecord&metadataPrefix=oai_datacite&identifier=oai:icatisis.esc.rl.ac.uk:inv/101134813
Provenance
Creator Dr Ed Mansfield; Dr Qiao Song; Dr Robert Dalgliesh; Professor Sebastien Perrier; Ms Julia Rho; Dr Stephen Hall; Miss Maria Kariuki
Publisher ISIS Neutron and Muon Source
Publication Year 2022
Rights CC-BY Attribution 4.0 International; https://creativecommons.org/licenses/by/4.0/
OpenAccess true
Contact isisdata(at)stfc.ac.uk
Representation
Resource Type Dataset
Discipline Biology; Biomaterials; Chemistry; Engineering Sciences; Life Sciences; Materials Science; Materials Science and Engineering; Natural Sciences
Temporal Coverage Begin 2019-03-26T00:00:00Z
Temporal Coverage End 2019-03-29T09:05:54Z