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Effect of formulation method and lipid composition on liposome lamellarity
Liposomes are vesicles comprising a phospholipid membrane bilayer around an aqueous core. They are well-established in the fields of drug delivery and diagnostics. To translate... -
Exchange kinetics of telechelic Cn-PEO-Cn micelles: effect of conformation an...
The microscopic dynamics of associative polymers that self-assemble into micellar structures play a key role for their macroscopical properties, with important implications for... -
Controlling Biosurfactant self assembly in solution.
Biosurfactants are becoming more commonplace in pharmaceuticals, vaccines and other forms of medicines. With the biobased economy growing substantially and pressure to reduce... -
Polymer-Lipid Nanodisc Self-assembly Processes Using Stop Flow
Polymer stabilized lipid nanodiscs offer enormous potential as tools for enabling membrane protein structural studies & biophysics. Polymer stabilized lipid bilayer discs... -
SANS studies of the micellar structure of C12-L-Carnitine and C14-L-Carnitine...
Acyl L-Carnitines are a group of novel surfactants with attractive physical and biological properties associated with their head group charge features. This work proposes to use... -
Mechanisms of shear stability in emulsions
High internal phase water-in-oil emulsions can be efficiently stabilised by polymer amphiphiles for a static emulsion, and also show high shear stabillity even at elevated... -
SANS study of the interaction of model plant leaf waxes with non-ionic surfac...
The understanding of the plant wax-surfactant interaction process is crucial to the development of more effective pesticide and fungicide formulations, essential for improving... -
Polymer-Lipid Nanodisc Self-assembly Processes Using Stop Flow
Polymer stabilized lipid nanodiscs offer enormous potential as tools for enabling membrane protein structural studies & biophysics. Polymer stabilized lipid bilayer discs... -
Solvation of cellulose-derivate polyelectrolyte in mixed solvents and added s...
Carboxymethylcellulose (NaCMC) is the most widely used cellulose derivative; it forms an anionic, water-soluble, polyelectrolyte with vast applications in the food,... -
Modulating Tetronics self-assembly with cyclodextrins for drug delivery appli...
Amphiphilic linear surfactants based on PEO and PPO triblock copolymers, known as Pluronics, exhibit a rich polymorphism and have been extensively studied for their applications... -
Biomolecular Cryoprotection in Deep Eutectic Solvents
Protecting biomolecules, such as proteins and enzymes, from the effects of cooling and freezing is important for the storage and handling of pharmaceuticals. Deep eutectic... -
SANS Investigation into the Mode of Interaction between Antibiotics and Diffe...
In this part of proposed work, we wish to explore how antibiotics minocycline and tetracycline interact with model lipid bilayers in the form of SUVs, mimicking key features of... -
Validating calorimetric self aggregation models: Self aggregation of cationic...
Ligand self aggregation is a common problem when studying interactions with bio(macro)molecules. In particular for techniques requiring relatively high ligand concentrations,... -
The role of chirality on polymeric membrane lytic activity
The human body has a well developed membrane chemistry which allows transport of fluids and salts whilst preventing other molecules and harmful agents from penetrating the cell.... -
In situ SANS study of a protein- graphene oxide (GO) co-assembly system
Supramolecular chemistry offers an exciting opportunity to assemble materials with molecular precision. However, there remains an unmet need to turn molecular self-assembly into... -
Telechelic Polymer - Homopolymer Blends
We have recently embarked on a new 1 year project funded by Michelin to explore the self-associatation and mechanical properties of telechelic rubbery materials. Such materials... -
Small angle neutron scattering experiment of a novel pH and temperature sensi...
The aim of the present study is to investigate the effect of different stimuli on a novel iron oxide core shell nanoparticles. The system is composed of a magnetite core with a... -
SANS studies on the structures of non-ionic surfactant micelles with/without ...
SANS is about the only technique that can determine the size and shape of surfactant micelles and the subsequent changes upon pesticide solubilisation. The aim of this work is... -
Assessing a potential method to form kinetically trapped, self-assembling nan...
Cyclic peptide-polymer conjugates can readily self-assembly into long nanotubes, and are being extensively studied for drug delivery applications. Recently, using SANS and... -
Mechanism of Wax Anti-Settling Additives and their role within Wax Crystallis...
Wax anti-settling additives are used to limit the sedimentation of wax crystals by reducing the crystal size and improving the stability of the wax crystal suspensions. The two...