Lipid exchange between high density lipoprotein (HDL) and model phosphatidylcholine membranes: the effect of unsaturation and cyclic species

DOI

Lipoproteins are the main carriers of lipids in the body. HDL is believed to favor cholesterol removal and decrease the risk to develop atherosclerosis and related cardiovascular diseases. Impact of the results. We have developed protocols to understand lipid exchange between lipoproteins and model membranes using neutron reflection. We have studied the exchange processes between HDL and saturated lipids as well as a natural extract, in the presence and absence of cholesterol. Surprisingly, the presence of cholesterol has little effect on lipid exchange but the natural extract behaves significantly different than the saturated lipids. Here we plan to clarify whether this effect is due to the presence of unsaturations, the presence of cyclic structures or the complexity of the lipid mixture in the dPC extract.

Identifier
DOI https://doi.org/10.5286/ISIS.E.98002370
Metadata Access https://icatisis.esc.rl.ac.uk/oaipmh/request?verb=GetRecord&metadataPrefix=oai_datacite&identifier=oai:icatisis.esc.rl.ac.uk:inv/98002370
Provenance
Creator Dr Dainius Jakubauskas; Dr Rebecca Welbourn; Miss Sarah Waldie; Dr Selma Maric; Professor Marité Cárdenas Gómez; Mr Rami Iskif; Dr Maxmilian Skoda; Mr Nico Koenig
Publisher ISIS Neutron and Muon Source
Publication Year 2021
Rights CC-BY Attribution 4.0 International; https://creativecommons.org/licenses/by/4.0/
OpenAccess true
Contact isisdata(at)stfc.ac.uk
Representation
Resource Type Dataset
Discipline Biology; Biomaterials; Engineering Sciences; Life Sciences; Materials Science; Materials Science and Engineering
Temporal Coverage Begin 2018-09-27T08:00:00Z
Temporal Coverage End 2018-10-01T08:00:00Z