16 datasets found

Biological membrane mimics are a bottle neck in biophysical studies today. The need to develop advanced models that actually represent the properties of specific cellular...

The yeast Candida glabrata is becoming an increasing cause of infections. We have developed RNA interference tools that allow us to study the virulence and resistance mechanisms...

Cyclic peptide-polymer nanotubes can readily self-assembly into long nanotubes, and are being extensively studied for drug delivery applications. As such, understanding how...

Bacterial membranes contain safety valves called mechanosensitive ion channels, which protect the bacterium from changes in the osmotic pressure of their environment. However,...

Myelin is the multilamellar structure that ensheaths axons and accelerates nervous impulses in the nervous system. The fine structure of myelin remains to be further...

Conventional ways to administer and deliver drugs have reached its limitations. These methods can be still used for small and simple molecules. However, new carriers have to be...

Salivary films are (mostly) proteinaceous nm-thick films that form on any type of surface upon exposure to saliva. The role of the pellicle is manifold. Among its functions,...

The current project aims at elucidating how bile salts (BS) structure influences their interfacial behaviour and their impact on fat digestion. Neutron reflectivity (NR) is the...

Exosomes are released by cells are responsible for cell-cell communication of macromolecules and the development of disease such as cancer. These nanoparticles are loaded with...

Atherosclerosis is the leading cause of death in western society, its consequences such as strokes and heart attacks arise from the build-up of plaques of fat which accumulate...

Many biological processes occur at the interface of cells, at the so called cell membrane, such as internalization of biological nanoparticles, including virions, exosomes and...

Gram negative (-ve) bacteria possess numerous defenses against antibiotics, not the least of them being the intrinsic permeability barrier afforded by their outer membrane (OM)...

Protein adsorption at solid-liquid interfaces plays a key role in biomedical technologies such as biosensors or biomaterials for medical implants. Despite considerable progress...

We propose to investigate antimicrobial peptides that self-assemble into well-defined nanostructures. Previous SAXS results have shown that the peptides form rather robust...

The goal of this project is to understand the antimicrobial activity of the intrinsically disordered salivary protein Histatin 5, which acts in defence against oral candidiasis...

Lipoproteins are the main carriers of lipids in the body. HDL is believed to favor cholesterol removal and decrease the risk to develop atherosclerosis and related...