This experiment will provide key information on the solution behaviour of novel polymer constructs designed as drug-delivery vectors. Is is known that solution behaviour of many polymer-drug conjugates is strongly influenced by covalently attached drugs, and that performance indicators such as circulation times within the body, uptake at tumour sites and into cell, drug release kinetics and polymer biodegradability are all influenced by apparent size and shape of the conjugate. Here, novel series of poly(glutamic acid) based polymers have been prepared with block, linear and branched (star, comb, dendritic) structures. Conformation of these architecturally constrained conjugates are predicted to be less affected by drug payload, but it is essential to demonstrate whether this is the case by extensive physico-chemical characterisation, in which SANS plays a key role.