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Study of the interaction of thermoresponsive naogels with lipids
This proposal seeks to characterise the hydrophobic interaction of thermoresponsive nanogels designed for drug delivery through the skin with a lipid monolayer as a function of... -
Conformational analysis of subtilin / lipid II binary antibiotic/target membr...
Antibiotic resistance is pathogenic bacteria is a major clinical problem. Resistance to all antibiotiotic classes, currentl yin clinical use, has been reported. By contrast, the... -
Probing the structure/function relationship of NhaA protein incorporated into...
We propose to perform combined measurements of neutron reflectometry (NR) and impedance spectroscopy (IS) to investigate the structure/function relationship of tethered bilayer... -
Dynamical properties of liposomes made of dimycolate and monomycolate of treh...
The detailed functional characterization of an outer membrane for C. glutamicum is a major challenge for the future since it raises several questions regarding the resistance of... -
The effect of anionic lipid unsaturation on the interaction with cytochrome c
While peripheral membrane protein-lipid interactions were originally considered to be solely electrostatic in nature, it is now accepted that they encompass more complicated,... -
Self-assembling antimicrobial peptides: interactions with model lipid membranes
We propose to investigate antimicrobial peptides that self-assemble into well-defined nanostructures. Previous SAXS results have shown that the peptides form rather robust... -
Investigating a Dextrin-Phospholipase A2 Conjugate as a Trigger for Polymer E...
Recent research has demonstrated the potential of nanosized delivery systems for routine use in many diseases, eg cancer, viral diseases and rheumatoid arthritis [1,2], due to... -
Binding of DNA to Model Membranes in the Presence of Ca2+ Ions and a Membrane...
The aim of the present work is to gain an understanding of the interaction of DNA with the phospholipid bilayers. The effect of different forms of DNA, the presence of divalent... -
Structural study on the 3D arrangement of (hexa-acyl) lipid A in lipid membrane
This study will focus on the structural investigations of the bilayers formed on silicon substrates in which the outer leaf consists of DOPE/LPS mixtures. We aim is to achieve... -
Antimicrobial peptide-loaded nanogels and their interaction with lipid bilayers
Due to increasing antibiotic resistance, bacteria membrane disrupting antimicrobial peptides (AMPs) are of increasing interest as alternatives to classical antibiotics. AMPs are... -
Surface structure of monolayers formed by novel di- and tri-chain cationic li...
The aim of the present study is to the determine, using specular neutron reflection (SNR), the structure of layers formed by novel tri-chain cationic lipids in combination with... -
GISANS directed to study lipid bilayer structures on nanowire arrays
Nanowires are increasingly being used in life science to interact with living cells, for example as nanometer probes. The interaction between the cell membrane, i.e. a lipid... -
Function and Structure of Reconstituted Neurotransmitters in biomembranes
Neurotransmitter transporters recognize biogenic amines dopamine, serotonin, noradrenalin and γ-amino butyric acid (GABA). They all belong to the family of... -
Structure of Meibomian lpid films at the air-water interface using
The tear film of the eye has an outer meibomian lipid layer (TFLL) that allows tears to spread across the eye and remain stable. Our Langmuir trough and other studies show that... -
The interaction of cytochrome c with floating bilayers containing negatively ...
As research on apoptosis has gained momentum, the importance of membrane lipids in this crucial cellular process is becoming clear.Previously, we have determined using NR and... -
Draft genomes of the algae Tisochrysis lutea strains
In a context of human population increase and depletion of terrestrial resources, exploitation of microalgae is an ecofriendly alternative path for the future. Currently,...
