27 datasets found

Multiple displacement amplification is a useful strategy for amplifying micrograms of DNA from picograms of material. Here we investigate the utility of using MDA for HiFi...

C. elegans are exposed to a variety of pathogenic and non-pathogenic bacteria species in their natural environment. Correspondingly, C. elegans has evolved an ability to discern...

Platanus-allee, a new de novo haplotype assembler, was developed and benchmarks of haplotype construction abilities of multiple tools were performed. The target samples were...

In this study, we aimed to identify mRNAs that are polyadenylated by TENT5 non-canonical poly(A) polymerases in Caenorhabditis elegans and murine macrophages using genome-wide...

We present DRUID (for Determination of Rates Using Intron Dynamics), a computational pipeline, for determining mRNA stability transcriptome-wide uses metabolic labeling and...

We are testing new wet-lab protocols designed to sample long reads, linked reads, Hi-C libraries, and cDNA libraries, all from single meiofaunal (<1 mm) specimens. This data...

Background: The interplay between hosts and their associated microbiome is now recognized as a fundamental basis of the ecology, evolution and development of both players. These...

Provide imperative insights into researching the physiological changes of marine and terrestrial organisms in response to changing nutritional environments.

Comparison of small RNA profiles across nematode evolution Overall design: Sequencing of small RNAs (15-33nt)

Proteins begin to fold as they emerge from translating ribosomes. The kinetics of ribosome transit along a given mRNA can influence nascent chain folding, but the extent to...

The RNA methyltransferase NSUN5 modulates the lifespans of yeast, worms and flies by re-programming the translation of specific subsets of mRNAs, which are associated with the...

The project has surveyed the intestinal nematodes from wild mouse lemurs in Ranomafana National Park, Madagascar and has developed a pipeline to identify these nematodes which...

Here, we compared ribosomal depletion methods in Brugia malayi (B. malayi) containing the symbiotic endosymbiont Wolbachia. We sequenced total RNA, Terminator exonuclease...

This data is part of a pre-publication release. For information on the proper use of pre-publication data shared by the Wellcome Trust Sanger Institute (including details of any...

Ribosomes undergo substantial conformational changes during translation elongation to accommodate incoming aminoacyl-tRNAs and translocate along the mRNA template. We used...

The identification of DNA G-quadruplexes (G4s) in the genome is important to study different biological processes in which these structures play a role, such as genome...

The identification of molecular biomarkers for iron ore contamination in Epinephelus marginatus may assist the biomonitoring of aquatic ecossystems nearby mining companies

Study somatic mutation in animal tissues, including mutation burden accumulation through lifespan and mutational signatures.

The nematode family Strongyloididae is of particular interest because it contains important parasites of medical and veterinary relevance. In addition, species of this family...

Many nematode species are parasitic and threaten the health of plants and animals, including humans, on a global scale. Advances in DNA sequencing techniques have allowed for...