The hydration and ordering of lamellar block copolymer films prior to the formation of polymer vesicles

DOI

For polymer vesicles to act as effective molecular delivery systems we must efficiently encapsulate a molecular payload within the vesicle. We would like to use neutron reflectivity to probe the non-equilibrium mechanisms that underlie vesicle formation for a series of model vesicle forming block copolymers. The experiment involves studying the hydration and ordering of lamellar block copolymer films prior to the formation of polymer vesicles. As we would like to understand the processes by which the block copolymer film orders prior to vesicle formation. The TS2 instrument INTER will enable us to follow the kinetics of the phase changes and swelling of the lamellar layers and hopefully enable strategies that will improve encapsulation efficiencies making these materials more viable for use as drug delivery agents.

Identifier
DOI https://doi.org/10.5286/ISIS.E.59896541
Metadata Access https://icatisis.esc.rl.ac.uk/oaipmh/request?verb=GetRecord&metadataPrefix=oai_datacite&identifier=oai:icatisis.esc.rl.ac.uk:inv/59896541
Provenance
Creator Dr Steven Parnell; Dr Roger Pynn; Dr Adam Washington; Mr Masaharu Ibaragi; Professor Richard Jones; Dr Andrew Parnell; Mr Yohei Kamata
Publisher ISIS Neutron and Muon Source
Publication Year 2017
Rights CC-BY Attribution 4.0 International; https://creativecommons.org/licenses/by/4.0/
OpenAccess true
Contact isisdata(at)stfc.ac.uk
Representation
Resource Type Dataset
Discipline Biology; Biomaterials; Chemistry; Engineering Sciences; Life Sciences; Materials Science; Materials Science and Engineering; Medicine; Natural Sciences; Physics
Temporal Coverage Begin 2014-08-15T23:00:00Z
Temporal Coverage End 2014-08-16T23:00:00Z