The TAlPro cruise (Palermo - Barcelona, RV Angeles Alvariño, 18/-8/2016 - 29/08/2-16) occupied three hydrographic transects across the Tyrrhenian Sea, the western Mediterranean Sea and the Catalan Basin (Fig. 1) as part of the MedSHIP programme (Mediterranean Ship-based Hydrographic Investigations Program). A total of 43 stations were occupied during which physical (temperature, salinity, pressure, velocity), biogeochemical (oxygen, nutrients, carbonate system, dissolved Barium, oxygen and nitrogen isotopes) and anthropic (CFCs, SF6) parameters were measured in order to monitor the physical and biogeochemical state of the Mediterranean Sea.