Sympathetic Stimulation Can Compensate for Hypocalcaemia-Induced Bradycardia in Human and Rabbit Sinoatrial Node Cells (v2.0)

DOI

This experiment offers the possibility to simulate the extended sinoatrial node cell models of Severi et al. (2012) and Fabbri et al. (2017) with several [Ca2+]o and [ISO]. The extension of the AC-cAMP-PKA signalling cascade is based on the work of Behar et al. (2016) and described by Linder et al. (2025).

Identifier
DOI https://doi.org/10.35097/u1nydar4kert7ra2
Related Identifier IsNewVersionOf https://doi.org/10.35097/qec954fvka86gcjw
Metadata Access https://www.radar-service.eu/oai/OAIHandler?verb=GetRecord&metadataPrefix=datacite&identifier=10.35097/u1nydar4kert7ra2
Provenance
Creator Linder, Moritz (ORCID: 0009-0000-1228-159X); Loewe, Axel ORCID logo
Publisher openCARP
Contributor RADAR
Publication Year 2025
Funding Reference European High-Performance Computing Joint Undertaking EuroHPC (JU) https://ror.org/00k4n6c32 ROR 101172576 https://microcard.eu Numerical modeling of cardiac electrophysiology at the cellular scale (MICRCOARD-2)
Rights Open Access; Apache License 2.0; info:eu-repo/semantics/openAccess; http://www.apache.org/licenses/LICENSE-2.0
OpenAccess true
Representation
Language English
Resource Type Simulation code; Software
Format application/x-tar
Discipline Biology; Computer Science; Computer Science, Electrical and System Engineering; Construction Engineering and Architecture; Engineering; Engineering Sciences; Life Sciences; Medicine