Aggregation behaviour of PEGylated ibuprofen

DOI

In the present study the acidic, anti-inflammatory drug, ibuprofen has been PEGylated using an polyoxyethylene chain of 750 molecular weight. The consequence of this PEGylation is the preparation of an amphiphilic, unionized version of the drug. The aim of the study is to determine the aggregation behavior of the molecule in aqueous solution using small angle neutron scattering in combination with contrast variation. The ultimate goal of the project is the preparation of a version of ibuprofen that can be administered safely in the form of a self-assembled micelle in which ibuprofen acts as its own delivery vehicle.

Identifier
DOI https://doi.org/10.5286/ISIS.E.RB1910532-1
Metadata Access https://icatisis.esc.rl.ac.uk/oaipmh/request?verb=GetRecord&metadataPrefix=oai_datacite&identifier=oai:icatisis.esc.rl.ac.uk:inv/103215698
Provenance
Creator Professor Jayne Lawrence; Dr Dave Barlow; Dr Najet Mahmoudi; Dr Manikandan Kadirvel; Dr Mark Jackman; Mr Weimin Li; Dr Alice Spadea; Dr Yu Lu; Miss Yixuan Yan
Publisher ISIS Neutron and Muon Source
Publication Year 2022
Rights CC-BY Attribution 4.0 International; https://creativecommons.org/licenses/by/4.0/
OpenAccess true
Contact isisdata(at)stfc.ac.uk
Representation
Resource Type Dataset
Discipline Biology; Biomaterials; Engineering Sciences; Life Sciences; Materials Science; Materials Science and Engineering
Temporal Coverage Begin 2019-06-13T08:00:00Z
Temporal Coverage End 2019-06-15T08:00:00Z