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Characterisation of Hybrid Lipid-Polymer Nanoparticles
Hybrid lipid-polymer nanoparticles have demonstrated potential as drug delivery vehicles. The current proposal aims to use small angle neutron scattering (SANS) in combination... -
Structure and gelation of poloxamer based hydrogels for injectable drug delivery
We seek to develop hydrogel formulations for injectable controlled drug delivery from Pluronics to enhance patient compliance, decrease side effects and reduce dose and... -
Time-resolved SANS of RNA packaging into virus capsids: Effect of RNA on the ...
The genetic code of viruses is typically protected by a spherical protein container. This protein capsid is assembled from hundreds of individual proteins in a spontaneous... -
Correlating the Internal Structure of Drug-Loaded Polymeric Nanoparticles to ...
The understanding the drug release mechanism from polymeric nanoparticles (PNPs) requires a detailed characterisation of the PNPs internal structure. Small-angle neutron... -
Lipid exchange in circularized nanodiscs
Nanodiscs (NDs) are discoidal lipid-protein aggregates composed by a lipid bilayer surrounded by a protein belt. NDs are suitable systems to investigate membrane protein... -
Interactions of Cationic Surfactants with Phospholipid Vesicles: Influence of...
Surfactants are frequently used in personal care products to improve the wetting and oil solubilizing qualities of the products, which also leads to the skin irritation by... -
Structural Changes in Micellar Self-Assemblies of Amphiphilic Drugs in Aqueou...
This study aims the micelle size and shape phase transition investigation for the amphiphilic drugs; adiphenine-HCl (antihistamine), amitriptyline-HCl (antidepressant), and... -
Self-assembly in ethyl ester sulfonate surfactants in the presence of electro...
The methyl ester sulfonate. MES, and ethyl ester sulfonate, EES, are representative of a promising group of anionic surfactants which have the potential for improved performance... -
Contrast variation SANS to understand drug directed assembly of multi lamella...
Recurring infection following dental interventions such as fillings is the most common reason for failure, leading to further treatments including root canal therapy, where the... -
Aggregation behaviour of PEGylated ibuprofen
In the present study the acidic, anti-inflammatory drug, ibuprofen has been PEGylated using an polyoxyethylene chain of 750 molecular weight. The consequence of this PEGylation...