The interaction of oxidatively damaged lung proteins with anionic lipids
Lung surfactant protein B, SP-B, interacts with lipids at the air-water interface of the lung where its presence is vital for correct respiratory function. SP-B and its synthetically available construct Super-Mini B, SMB, are known to be damaged by exposure to the ubiquitous gas-phase pollutant ozone but remain at the air-water interface in damaged form. The exposure leads to the conversion of neutral side changes into negatively charged side chains. What is less clear is how these damaged peptides interact with negatively charged lipids that are also required at the air-water interface. In this work we will look at the interaction between the initially positively charged peptide SMB and the negatively charged lipid 1,2-dipalmitoyl-sn-glycero-3-[phospho-rac-(1-glycerol)], DPPG, before and after exposure to a dilute flow of ozone gas.
- 0 25
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- 1210193
- 1H DPPG
- 1N Au Thiolipid 4MW
- 1N Au Thiolipid D2O
- 1N Au Thiolipid H2O
- 1N Au Tholipid D2O
- 2 dipalmitoyl sn gl...
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- 2H DPPG
- 2HPOPG
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- 6N Au Tholipid D2O
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- AIr
- Beryllium
- Block
- C38H12O10PNaD62
- C38H74O10PNa
- D2O
- DETHEIGHT
- Filters
- HEIGHT
- Hemming
- Hughes
- Multidet
- PHI
- Qtz DPPC cmQ H2O2
- Qtz DPPC cmQ NaOCl
- Qtz DPPC cmQ NaOCl ...
- Qtz cmQ NaOCl H2O2
- Quartz
- Quartz D2O
- RKT
- Rennie
- Run
- S1
- SI AIr
- SMB
- SMB_2HPOPG
- SURF
- Scanning
- The
- Thompson
- Transmission
- again
- air
- air cmw
- anionic
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- axis
- block
- buffer
- compression
- compression1
- compression2
- compression3
- d62 1
- damaged
- interaction
- lipids
- lung
- no
- no ozone
- oxidatively
- ozone
- post
- pre ozone
- proteins
- run
- smb
- smb_2HPOPG
- tRansmission
- test
- transmission
- tube
- vacuum
Provenance | |
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Creator | Dr Arwel Hughes; Dr Katherine Thompson; Miss Joanna Hemming; Professor Adrian Rennie |
Publisher | ISIS Neutron and Muon Source |
Publication Year | 2015 |
Rights | CC-BY Attribution 4.0 International; https://creativecommons.org/licenses/by/4.0/ |
OpenAccess | true |
Contact | isisdata(at)stfc.ac.uk |
Representation | |
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Resource Type | Dataset |
Discipline | Photon- and Neutron Geosciences |
Temporal Coverage Begin | 2012-06-06T07:57:36Z |
Temporal Coverage End | 2012-07-21T09:25:47Z |