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Effect of formulation method and lipid composition on liposome lamellarity
Liposomes are vesicles comprising a phospholipid membrane bilayer around an aqueous core. They are well-established in the fields of drug delivery and diagnostics. To translate... -
Engineering nanoparticles for protein therapeutics - quantifying membrane acc...
The self-assembly properties of lipid systems can be exploited to form lipid membranes with complex morphologies. These include membranes with a lattice-type internal structure... -
Formulating polymer solutions to stabilise polymeric foams
Polyurethane foams (PUFs) are commonly prepared by mixing Pluronic type copolymers and isocyanate reactive monomers in the presence of additives e.g. catalysts, blowing agent... -
Cationic surfactants as non-covalent linker for cellulose nanofibrils and sta...
This proposal forms part of an ongoing project concerning interpenetrating network gels of starch and cellulose being developed towards applications in personal care and... -
Self-assembly of lipid and triblock copolymer-based amphiphiles for drug deli...
Soft self-assembled structures have been extensively used as drug nanocarriers. Their building blocks, naturally occurring and synthetic amphiphiles (lipids or block... -
Competitive interactions in polymer-particle-surfactant blends
Many formulations comprise distinct chemical species that exhibit antagonistic or synergistic interactions that result in unpredictable behaviour. Previous work from our group... -
Molecular Mechanistic Processes of Complexation between DNA and Cationic Copo...
It is difficult for the naked external gene to become internalized due to its similar charge to the extracellular membrane surface. Various cationic copolymers and cationic... -
The influence of chemical pressure on the helimagnetic correlatations and sky...
The recent discovery of skyrmions and skyrmion lattices in materials with no inversion symmetry and their corresponding potential applications of Skyrmions in magnetic... -
The impact of synthetic perfumes on surfactant self-assembly.
This proposal is part of a broad collaboration between Oxford, CCLRC, and Unilever in the study of surfactants and mixed surfactants at interfaces and in solution. This is an... -
Solution aggregation of short peptide surfactants
Short peptide sequences consisting of hydrophobic and hydrophilic amino acid units are capable of self-assembly to lead to interfacial adsorption and solution nano-aggregation.... -
Structure determination of solution aggregation of single alkyl chain PC surf...
We have synthesised alkyl phosphorylcholine (CnPC) surfactants in hydrogenated and deuterated form and have determined their solution aggregation using SANS. In this part of... -
Rapid microfluidic phase mapping of SDS:water:butanol
Sodium dodecyl sulfate (SDS) is an anionic surfactant, extensively employed in cosmetics and personal care, as well as in pharmaceuticals and food products. Surfactants are... -
Effect of drug on the micelles formed by ionic surfactants
The aim of the study is to use SANS in combination with contrast variation to determine the effect of solubilising the lipophilic drug, testosterone propionate, in micelles... -
Competition at the nanoparticle surface: one polymer, two surfactants, many p...
Polymers and surfactants are key components in detergency. Understanding their interactions is essential to formulate smartly. Detergent formulations usually contain a mixture... -
Mixing of phospholipids and block copolymers in a polymersome membrane
We wish to measure polymersomes having a long PEO chain which we develop for radionuclide encapsulation and which we believe improves blood circulation in vivo. Specifically we... -
Molecular Mechanistic Processes of Complexation between DNA and Cationic Copo...
We have previously used LOQ to identify the complex (polyplex) structures formed between a short single strand DNA and a cationic diblock copolymer MPC30-DEA60. The SANS... -
Effects of pH and ionic strength on stability and structure of lipid-polymer ...
Nanostructured lipid aggregates offer enormous potential as tools for membrane structural biology and biophysics. Styrene-Maleic Acid Lipid Particles have a number of attractive... -
Characterisation of self-assembly in cationic-oligoanion mixtures: from micel...
The proposal is part of an EPSRC funded programme (EP/GR065705) on surfactant multilayer structures, and involves the interaction between ionic surfactants and oligoions. It... -
Modulating Tetronics self-assembly with cyclodextrins for drug delivery appli...
Amphiphilic linear surfactants based on PEO and PPO triblock copolymers, known as Pluronics, exhibit a rich polymorphism and have been extensively studied for their applications... -
Simultaneous SANS and modulated SESANS studies of cross-linking in cellulose ...
Recently we have trialled the new techniques enabled on Larmor which permit simultaneous measurements of nanoscale and macroscale structure. These experiments gave new insights...