Understanding the interfacial behaviour of bile salts to better engineer lipid emulsions: small-angle neutron scattering measurements

DOI

The current project aims to 1) elucidate how bile salts (BS) structure influences their interfacial behaviour and role during lipolysis; 2) to study the potential ability of specific food emulsifiers to inhibit BS adsorption, and thus lipase adsorption, at the lipid/water interface. Small-angle neutron scattering beam time is requested here to investigate BS self-assembly in the bulk and to characterise the structure of emulsion droplet interfaces stabilised by food emulsifiers, after interaction with BS and lipase/co-lipase. Two structurally different BS showing contrasting interfacial behaviours have been selected in this work. Three methylcelluloses are chosen as emulsifiers due to their demonstrated cholesterol-lowering capacity. BS adsorption at droplets interfaces will be studied and equilibrium structures after interaction with lipase measured, as a function of BS type and amount.

Identifier
DOI https://doi.org/10.5286/ISIS.E.90588176
Metadata Access https://icatisis.esc.rl.ac.uk/oaipmh/request?verb=GetRecord&metadataPrefix=oai_datacite&identifier=oai:icatisis.esc.rl.ac.uk:inv/90588176
Provenance
Creator Miss Suzette Lust; Ms Tong Yu; Professor Peter Wilde; Dr Isabelle Grillo; Dr Olivia Pabois; Dr Richard Harvey; Dr Najet Mahmoudi; Dr Cecile Dreiss
Publisher ISIS Neutron and Muon Source
Publication Year 2021
Rights CC-BY Attribution 4.0 International; https://creativecommons.org/licenses/by/4.0/
OpenAccess true
Contact isisdata(at)stfc.ac.uk
Representation
Resource Type Dataset
Discipline Chemistry; Natural Sciences
Temporal Coverage Begin 2018-02-14T09:00:00Z
Temporal Coverage End 2018-02-19T09:00:00Z