-
Structure of responsive PNIPAM-PAAc microgels
We propose to investigate a temperature and pH responsive microgel composed of Interpenetrating Polymer Networks (IPN) of poly(N-isopropylacrylamide) (PNIPAM) and poly(acrylic)... -
Engineering nanoparticles for protein therapeutics - quantifying membrane acc...
The self-assembly properties of lipid systems can be exploited to form lipid membranes with complex morphologies. These include membranes with a lattice-type internal structure... -
Molecular interactions and protein stability in the accessory gene regulator ...
Staphylococcus aureus is a normal skin commensal and an opportunistic pathogen that presents serious threat to healthcare. It is the causative agent of septicaemia and... -
Investigation of Folded Globular Maltose Binding Protein Based Hydrogels
We have developed a new model to describe the structural architecture of hydrogels composed of cross-linked maltose binding proteins (MBP), supported by multiple techniques... -
Structure of Cellulose Nanofibril Gels with Different Surfactants
This proposal is part of a project based on understanding the formation of gels in suspensions of partially oxidised cellulose nanofibrils and small amounts of additives, such... -
Study of cooperative aggregation of organic semiconductor in solution
Soluble pentacene derivatives are high performing semiconductors for use in organic transistors offering low cost solution processability, and potential for migration to... -
Effect of pH on the complexation behaviour between Pluronic micelles, drugs a...
Pluronic micelles are attractive candidates as drug carriers. Despite the abundance of data on their association with various drugs, there is, in contrast, very little... -
Structural Observation of the Self-Assembly Kinetics of Cyclic Peptide Nanotubes
Cyclic peptides with alternating side chain stereochemistry are capable of self-assembling into long nanotubes. The conjugation of polymers to these peptides renders the... -
Interaction of the intrinsically-disordered linker histone C-terminal tail wi...
In cells, the genome needs to be tightly packaged in the nucleus as "chromatin" while still allowing access to the cellular machinery responsible for gene expression. The first... -
Mixed surfactants for positive synergism in dense CO2
This proposal aims to explore a cheaper and more environmental-benign surfactant system for yielding efficient water/CO2 microemulsions. The new surfactants permit high... -
SANS Studies of Novel Internally Stabilised Liposomes
Internally supported liposomes (ISLs) are composed of polymeric spheres enclosed by liposomes. Although very little research has been done on ISLs, understanding their... -
Small-angle neutron scattering study of human growth hormone-surfactant compl...
Liquid pharmaceutical formulations are commonly comprised of proteins and surfactants, which interact in solution in order to provide an increase in system stability. Although... -
Structural changes of lecithin wormlike micelles by adding solutes
Lecithin is a natural zwitterionic gemini surfactant that self-assembles in a hydrocarbon solvent, forming spherical or ellipsoidal inverse micelles, which grow into giant... -
Solvent-induced curvature of micelles
The purpose is to follow a structural evolution as water soluble (normal curvature) micelles are gradually transformed into oil soluble (reversed curvature) aggregates. Although... -
Probing the bulk morphology of fullerene-free organic solar cell blends using...
The aim of this project is to develop an understanding of the relationships between the processing, nanoscale structure and device performance of bulk heterojunction,... -
Unravelling the solution structures and stability of industrially-important a...
The glycosylation of glycoproteins is a major determinant of their stability, and glycans also affect their aggregatibility (precipitation). An understanding of this is... -
The action of membrane lytic compounds on model membranes.
The study of antifungal and antibacterial action is of great interest and there are still many unknowns concerning the action of membrane lytic materials, and the way that... -
Structural analysis of amino acyl-tRNA-dependent Ligation Reactions in Bacter...
Assembly of the peptidoglycan later of bacterial cell walls is a validated target for anti-bacterial agents: the late transpeptidation and transglycosylation steps are inhibited... -
Molecular Mechanistic Processes of Complexation between DNA and Cationic Copo...
It is difficult for the naked external gene to become internalized due to its similar charge to the extracellular membrane surface. Various cationic copolymers and cationic... -
Aggregation behaviour in solution of cationic conjugated polymers and oligomers
In the proposed experiments we extend previous work on characterization of aggregates formed by cationic conjugated polymers and oligomers in water. Particular emphasis will be...