Bioturbators (such as bivalves, worms, polychaetes), living in a coastal area, experiences frequent changes in salinity. They are often exposed to mechanical disturbances (like wave, currents, storms) forcing them to bury deeper into the sediment to get a better foothold. In nature, these stressors often occurs simultaneously. Osmotic stress negatively affects the burial activity and the physiological performances of soft shell clam, Mya arenaria; however, the mechanism behind this is still unknown. In this dataset we present the combined effect of osmotic stress and repeated burrowing on the activity leucine aminopeptidase in gill tissue and digestive gland of Mya arenaria.