The UK Midlands BAG consists of groups located at the Universities of Birmingham, Leicester, Nottingham, and Keele. We represent a diverse spectrum of research interests, from microbiology, cancer biology, blood disorders, immunology to fundamental biological processes such as membrane transport, DNA repair and mechanisms of enzyme catalysis. Our groups use X-ray crystallography and cryoEM in conjunction with biophysical and biochemical techniques to elucidate molecular mechanisms of protein-protein and protein-ligand interactions. Our cooperation in this block allocation group is mirrored by the consortium of institutions that are stakeholders in the Midlands Regional CryoEM Facility at the University of Leicester.