This dataset contains results from simulations with the AWI Earth System Models AWI-ESM with two different model setups: one with an interactive ice sheet model (PISM) for the Greenland ice sheet domain and one without. With both model setups, the Representative Concentration Pathways scenarios RCP4.5 and RCP8.5 were simulated. The simulation runs were prolonged to the year 2200. We investigated the effect of the incorporated ice sheet model on the Atlantic meridional overturning circulation. As the ice sheet is not only melting but also growing in some areas, the freshwater release is partly compensated. Therefore, the effect on the Atlantic meridional overturning circulation is rather small.The dataset contains time series of global average temperature, atmospheric and oceanic freshwater fluxes for the Atlantic catchment area, several ice volume fluxes of the Greenland ice sheet, and the AMOC index. Furthermore, it contains spatial data mostly as anomalies (the last 30 year average minus the control state) of the Greenland ice sheet thickness and mass balance, sea surface salinity and sea ice concentration and precipitation minus evaporation and vertical profiles of anomalies of temperature, salinity, and density for the regions of deep water formation in the North Atlantic. All files are in the NetCDF format.