Wastewater has a predominant role for Public Health as source, reservoir and vehicle of antimicrobial resistance genes. This role is especially critical in developing countries and regions, where the limitation of resources and control measures favour the emergence, evolution and dissemination of novel multidrug-resistant bacteria. This study was conducted in order to identify the presence of bacteria highly resistant to carbapenems or/and aminoglycosides, as well as the responsible genetic mechanisms and the mobile genetic elements involved in its dissemination, from both wastewater of urban and hospital canalizations in the region of Tamale (Ghana), deciphering the epidemiological scenario and flux of these bacterial elements across the hospital-community interface. All samples are related to WGS Illumina data, assemblies and metadata.