In a pharmaceutical industry context, hydrophilic polymeric matrices are a popular methodology for extending the release of drugs. However, issues sometimes arise - unpredictable release behaviour in the fasted stomach, unexpected dose dumping (positive food effect) or unexpectedly slow release in the presence of food. Previously, we have shown a link between the fundamental interactions between representative drugs and hydroxypropyl methylcellulose (HPMC) in solution and their release profiles. Here, we wish to extend these studies to a wider range of drug and thus, to benchmark the observed physicochemical interactions with the already determined representative release profiles.