Modulation of gastro-intestinal permeability induced by 2 weeks consumption with 2 fermented milk products; a randomized, exploratory, cross-over, double blind, controlled study in ileostomy patients

Sugar permeability test in urine samples. 16 volunteers received treatments in different orders (Placebo, L. rhamnosus, Yogurt) and urine was collected after 2 and 5 hours. The samples were collected for the INSIDE explorative dietary study. The study was aimed to characterize the impact of fermented food may have on the small intestinal microbiota and systematically. Sucrose and Lactulose content in the urine was measured. Sucrose is hydrolyzed in the duodenum, and is therefore a good marker for gastroduodenal permeability, measured in 0-5h urine. Lactulose can permeate through the paracellular route and rhamnose through the transcellular route in the small intestine. The ratio in 0-5h urine is mainly used for general assessment of the SI permeability.

Identifier
DOI https://doi.org/10.17026/dans-xnp-nkq8
PID https://nbn-resolving.org/urn:nbn:nl:ui:13-57-jth8
Metadata Access https://easy.dans.knaw.nl/oai?verb=GetRecord&metadataPrefix=oai_datacite&identifier=oai:easy.dans.knaw.nl:easy-dataset:225198
Provenance
Creator Zaccaria, E.; Klaassen, T.; Alleleyn, A.M.E.; Boekhorst, J.; Smokvina, T.; Kleerebezem, M.; Troost, F.J.
Publisher Wageningen University & Research
Contributor Wageningen University & Research
Publication Year 2021
Rights info:eu-repo/semantics/openAccess; License: http://creativecommons.org/licenses/by/4.0; http://creativecommons.org/licenses/by/4.0
OpenAccess true
Representation
Language English
Resource Type Dataset
Format xlsx; csv
Discipline Other