The dataset contains meteorological observations during a measurement campaign with the drone LUCA (Lightweight high Ceiling Aerial System). The measurements were collected on flight 20211025_Flug1_LUCA1. As parameters, pressure, temperature, humidity and wind direction/speed were observed along with time and position of the drone. Besides the raw measurements, temperature and humidity readings have been corrected with an estimated inverse sensor transfer function. The data allows intercomparing the drone measurements with collocated radiosonde launches which enables a discussion on the possible use of the drone LUCA and similar systems for operational meteorology.