This BAG coordinates activities of groups from the South-West of the UK. The focus of the bag is on projects in Immunology, enzymology, and transcriptional regulation. A particular strength are the macromolecular complexes that several of the groups target. The activities in rational protein design (Bristol) and in cancer immunology and enzyme mechanism (Southampton) are particular highlights, with high profile publication. Cardiff has joined the bag as a new member in 2022. Several bag members are active in using facilities such as icOS and ID29 serial as pointed out in the proposal. NB although ID29 is a separate proposal at present, we have a new member with the University of Essex, expected to join this bag when ID29 is part of the bag proposal.