Skin becomes a target of drug delivery because the transdermal routes are non-invasive, can be self-administrated, improve patient compliance and can provide release for long periods of time. The challenge for transdermal delivery is that only a limited number of drugs are amenable to administration by this route, thus surfactant based drug carries has gained a lot of attention. Here we want to study the interactions between surfactant with different fluidity and model lipid membranes. Understandings of the lipid-surfactant interaction could provide more guidance for the selection of surfactant based drug delivery systems.