Drug solvation in amphiphilic solutions: understanding how small molecules cross the blood brain barrier

DOI

Understanding how drugs interact with physiologically relevant environments is crucial for the future of effective drug design. An important class of potential drugs are central nervous system (CNS) drugs which need to cross the blood brain barrier (BBB) in order function. In the current work, we propose to investigate the solvation structure of drugs which cross the BBB in model environments which mimic the hydrophobic/hydrophilic interface of the BBB.

Identifier
DOI https://doi.org/10.5286/ISIS.E.60998123
Metadata Access https://icatisis.esc.rl.ac.uk/oaipmh/request?verb=GetRecord&metadataPrefix=oai_datacite&identifier=oai:icatisis.esc.rl.ac.uk:inv/60998123
Provenance
Creator Mr Andrew Johnston; Dr Ric Gillams; Miss Luxmmi Varathan; Dr Sam Callear; Dr Sylvia McLain; Dr Luis Carlos Pardo-Soto
Publisher ISIS Neutron and Muon Source
Publication Year 2018
Rights CC-BY Attribution 4.0 International; https://creativecommons.org/licenses/by/4.0/
OpenAccess true
Contact isisdata(at)stfc.ac.uk
Representation
Resource Type Dataset
Discipline Chemistry; Natural Sciences
Temporal Coverage Begin 2015-03-30T08:00:00Z
Temporal Coverage End 2015-06-25T23:00:00Z