We propose to measure one or two big molecule systems. The aim of the experiment is to enable us to progress with single crystal data analysis using Mantid and also to provide a case for a future dedicated beamline. Whilst neutron has obvious advantages compared to X-rays for studying such materials, the lack of flux (or neutron size crystals) prevent this type of research being done routinely at neutron facilities. With new generation instruments coming on line, with higher flux and better signal to noise ratio, revisiting what can be achieved in this domain is very important.