The IBS BAG currently includes 24 IBS teams and 4 external groups from CERMAV and iRTSV/CEA (Grenoble), CEA-Cadarache (St Paul lez Durance) and IRBA (Brétigny-sur-Orge). We study structure-function relationships of proteins emphasizing in human health, biotechnology and methodology. Most of the projects can be grouped in different topics as follows: host-pathogen interaction, immunology, new drug targets, fundamental cellular mechanisms, membrane proteins, intrinsically disordered proteins, biotechnological applications and methodology. Some of these projects use integrative approaches (X-ray crystallography, SAXS, NMR (and cryo-EM), together with other biophysical studies) with the aim to fully understand the complexity of the biological macromolecular systems on study. Some other teams are dedicated to serial crystallography and its developments, for which the new ESRF-EBS might be the perfect tool.