Nanoemulsions have considerable potential for dermatological drug delivery. Small angle neutron scattering in combination with contrast variation will be used to characterize the microstructure of oil-in-water nanoemulsions prepared from two different oils, liquid paraffin and hexadecane and stabilized by a fatty alcohol/sodium dodecyl sulphate mixed emulsifier. In particular, the influence of emulsifier concentration on nanoemulsion microstructure will be investigated. The detailed structural information emulating from these studies will aid the rational design of dermatological nanoemulsions with improved stability.