An oral pH-responsive Streptococcus agalactiae vaccine formulation provides protective immunity to pathogen challenge in tilapia

DOI

Data related to the Table and figures in the publication (in title)    Table 1 shows Particle size measured by dynamic light scattering (mean±SD), n= 12 

Figure 5 shows   the Change in particle size (measured by dynamic light scattering) upon exposure to 0.1M HCl, which is simulating the acidic environment in a fasted tilapia stomach. Means are shown. Error bars reflect the SD. N=12

Fig 6 shows the pH measured in the different sections of the gastro- intestinal tract of fasted and fed tilapia (mean ± SD), N=5

Fig. 7 Shows the Cumulative percentage mortality in the 3 groups following oral gavage with: (ai) PBS in the negative control group; (aii) Blank Eudragit microparticles; (b) GBS-loaded Eudragit microparticles, and challenge by immersion using a homologous strain of Streptococus agalatiae sequence type on day 21 post-gavage. Error bars represent SD from 4 replicate tanks (25 fish per tank) for each of 3 treatment groups.

The data are shown in Excel files.  Data was collected using dynamic light scattering (Table 1, Figure 5), by measuring pH using a probe (Figure 6), and by counting the numbers of fish which survived the pathogen challenge with time. 

Identifier
DOI https://doi.org/10.5522/04/19369376.v1
Related Identifier https://ndownloader.figshare.com/files/34427294
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Metadata Access https://api.figshare.com/v2/oai?verb=GetRecord&metadataPrefix=oai_datacite&identifier=oai:figshare.com:article/19369376
Provenance
Creator Murdan, Sudax; Phuoc, Nguyen Ngoc; Basit, Abdul; N. Zadoks, Ruth; Herath, Tharangani ORCID logo; Bashir, Shazia ORCID logo
Publisher University College London UCL
Contributor Figshare
Publication Year 2022
Rights https://creativecommons.org/publicdomain/zero/1.0/
OpenAccess true
Contact researchdatarepository(at)ucl.ac.uk
Representation
Language English
Resource Type Dataset
Discipline Other