The use of magnetic contrast layers for neutron reflectivity to investigate non-lamellar lipid liquid crystalline nanoparticle interactions

DOI

The search for new clever ways to deliver drugs, which often are not possible to dissolved in water, has lead to the development lipid based small particles. These particles can dissolve many different types of drugs that so far has been hard to solubilize. They can be used on the skin, eaten and be injected. Although they are based on natural lipids they have an intriguing internal structure which explains the capability to solubilize the drugs. They are also sticky and can be design so that the interacts with cells, more specifically with the cell-membrane that keeps the cell intact. The cell membrane also consists of lipids, so we want to know how the particles interact with these membrane. We are here using models of membranes with different properties and we use neutrons to see what happens when the drug delivery particle meets the membranes.

Identifier
DOI https://doi.org/10.5286/ISIS.E.67767557
Metadata Access https://icatisis.esc.rl.ac.uk/oaipmh/request?verb=GetRecord&metadataPrefix=oai_datacite&identifier=oai:icatisis.esc.rl.ac.uk:inv/67767557
Provenance
Creator Mr Christopher Hirst; Miss Jenny Andersson; Professor Tommy Nylander; Dr Nina-Juliane Steinke; Ms Maria Valldeperas Badell; Dr Aleksandra Dabkowska; Dr Gunnar Palsson; Dr Justas Barauskas
Publisher ISIS Neutron and Muon Source
Publication Year 2018
Rights CC-BY Attribution 4.0 International; https://creativecommons.org/licenses/by/4.0/
OpenAccess true
Contact isisdata(at)stfc.ac.uk
Representation
Resource Type Dataset
Discipline Biology; Biomaterials; Engineering Sciences; Life Sciences; Materials Science; Materials Science and Engineering
Temporal Coverage Begin 2015-12-07T08:00:00Z
Temporal Coverage End 2015-12-13T08:00:00Z