This proposal will develop, and make available to the user community, a new experimental and algorithmic framework to conduct simulation informed multi-modal in situ experiments on metallic materials. This will allow to study the mechanical behaviour of polycrystalline samples at the microstructural scale (deformation, fracture). The establishment of automated acquisition and data processing pipelines will allow for the first time to use the feedback from experimentally driven simulations of the material response to guide subsequent “zoom-in” observations in selected regions of interest. Achieving this ambitious goal requires (i) a new, fully integrated, in situ load stage compatible with both id11 end stations (ii) an efficient data processing pipeline for DCT, topotomography and scanning-3DXRD acquisitions (both interactive & automated) and (iii) experimentally driven mechanical simulation routines to add stress/strain fields to the reconstructed data.