The aim of this proposal is to provide user access to Online crystallography and fragment screening pipelines based on the combination of EMBL’s HTX Lab services and the CrystalDirect Technology and automated data collection at ESRF’s MX beamlines, supported through the collaborative EMBL-ESRF Joint Structural Biology Group (JSBG). This will include three different user access modalities: 1) Large-Scale Fragment Screening, 2) Structural characterization of ligand-target complexes and 3) Online Crystallography (automated protein-to-structure pipeline). This work will be carried out in the context of international collaborative projects. Access to these modalities will require competitive application and peer-review through projects like the E.C. funded iNEXT Discovery or the recently awarded ISIDORe.