This BAG coordinates activities of groups from the South-West of the UK. The focus is on projects in Immunology, transcriptional regulation, and enzymology. A particular strength are the macromolecular complexes that several of the groups target. The activities in rational protein design (Bristol) and cancer immunology and enzyme mechanism (Southampton) are particular highlights. Cardiff is joining the bag as a new member. Please note comments in the report on COVID and sample shipment. Experimental work has been affected by Covid, which has reduced the output, and by travel restrictions. Further, we have had problems with loosing samples on transport as they were held up in customs, with three affected shipments. Due to these complexities Portsmouth have decided to leave the bag.