37 datasets found

In nucleophilic fluorination reactions it is extremely difficult to tune the reactivity of the fluoride anion in organic solution to give the desired product. Building on our...

Pluronic micelles are attractive candidates as drug carriers. Despite the abundance of data on their association with various drugs, there is, in contrast, very little...

This proposal addresses bilayer swelling experiements on floating supported bilayers (FSBs) in the presence of biological buffers. Previous work on multilamellar vesicles has...

Conjugation of therapeutic proteins to polymers is well established but most methods result in multi-site and multiple conjugation, crosslinking resulting in lack of orientation...

Bacteria growing resistant to common antibiotics is a growing problem and research in new types of medicines which do not induce resistance is therefore very important. Novel...

In recent years, it has become understood that rather than being homogenous mixtures, biomembranes show a complex phase behaviour, with regions of uniform phases, and others...

To date complexes prepared from vesicles composed of dichain, cationic lipids (L) with negatively charged DNA (D), known as LD complexes have emerged as one of the major...

Calcium ions have been shown in a preliminary experiment to have a dramatic effect on the thickness and structure of free supported bilayer films. In this proposal we...

Zwitterionic lipids such as phosphatidylcholine (PC) are major components of the membranes that compartmentalize organisms. Although there is a large literature on PC, cationic...

Fracture prediction of structures manufactured from high strength engineering steels is a high priority in key industries. In this work residual stress (RS) effects on creep...

What does a quantum particle do when you are not looking at it? For a classical moving object, like a golf ball, we know its trajectory even when we are not looking at it. This...

Ni-base superalloys have long been used in high temperature applications, including the high-demand environments of the high pressure turbines in jet engines. The remarkable...

Metal-organic frameworks are an exciting class of porous and crystalline materials exhibiting exceptional sorption properties. The growing interest in the community lies in the...

Recently we have been investigating the mineralization of polymer-surfactant films to create thicker and more robust self-supporting membranes. Our previous experiments used the...

The aim of the current project is to probe (at the nanometer length scale) the relationship between the solution structures of a surfactant molecule, the aggregate(s) it forms...

Nuclear power generation plants undergo start-up/shut-down load-temperature cycles during service operation. Components operating at temperatures in the creep regime can exhibit...

We request 3 days on MARI to investigate the effect of Q on the previously determined partial phonon density of states of a zeolite framework with a low concentration of...

The aim of this experiment is to characterise the effect of dilution on the residual stresses in multiple-pass welds produced with specially designed filler alloys that exploit...

Vesicles have spheroid structures composed of bilayers of amphiphilic molecules and widely used as models of cell membranes and as carriers for controlled drug delivery....

Stress corrosion cracking is an important degradation mechanism that is threatening the structural integrity of pressurised water reactors throughout the world. Dissimilar weld...