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Chromosomal Mcm2-7 distribution and the genome replication program in species...
The spatio-temporal program of genome replication across eukaryotes is thought to be driven both by the uneven loading of pre-replication complexes (pre-RCs) across the genome... -
RNA-Seq analysis of gene expression divergence in mammalian liver
The connection between evolution of regulatory elements and downstream gene expression is incompletely understood in mammals. We carried out a large-scale comparison of matched... -
qDSB-Seq is a general method for genome-wide quantification of DNA double-str...
DNA double-strand breaks (DSBs) are among the most lethal types of DNA damage and frequently cause genome instability. Sequencing-based methods for mapping DSBs have been... -
Xenosurveillance vs. finger-stick blood collection for the detection of human...
The sequencing data in this project was generated by either 1) xenosurveillance, or sequencing blood removed from mosquito abdomens, or 2) finger-stick human blood collected... -
Precise genome editing across kingdoms of life using retron-derived DNA
Sequencing data associated with the manuscript: "Precise genome editing across kingdoms of life using retron-derived DNA" -
Microbial community structure in the central Arctic Ocean
Bacterial and Archaeal community structure in the central Arctic Ocean -
Real-time transcriptomic profiling in distinct experimental conditions
Nanopore-sequencing offers real-time sequencing opportunities, providing rapid access to sequenced data and allowing researchers to manage the sequencing process efficiently,... -
Virome profiling of an Amur leopard cat reveals multiple anelloviruses and a ...
As a small top predator, Amur leopard cat (Prionailurus bengalensis euptilurus) is widely distributed in Northeast Asia and plays an important role in the control of small... -
Interferon inducible pseudouridine modification in human mRNA by quantitative...
Pseudouridine (?) is an abundant mRNA modification in the mammalian transcriptome, but its function has remained elusive due to the difficulty of transcriptome-wide mapping. We... -
Comparative analysis of amplicon and metagenomic sequencing methods reveals k...
Background: The interplay between hosts and their associated microbiome is now recognized as a fundamental basis of the ecology, evolution and development of both players. These... -
PAIR-MaP visualizes RNA base pairing complexity in human and bacterial non-co...
Structure probing experiments were performed on in vitro transcripts and E. coli and human cell cultures under natively extracted (cell-free) and in-cell conditions to benchmark... -
Assaying RNA Structure with LASER-seq
structure probing of ribosomes Overall design: Purified and in-vivo ribosomes are probed with Naz to identify structural features -
Dual-RNA sequencing of dendritic cells challenged with Aspergillus fumigatus
Dendritic cells and A. fumigatus were co-cultured with two different MOIs (1 or 0,5) for 2, 4 or 6 hours. Single-cultures of dendritic cells and A. fumigatus serve as controls.... -
Direct detection of RNA modifications and structure using single molecule nan...
In this study we use direct RNA nanopore sequencing to identify RNA modifications and structure. We perform modification detection on ribosomal RNA (rRNA) from E. coli and S.... -
RNA sequencing of host transcriptome of human foreskin fibroblast cells infec...
The purpose of this data set is to determine if bradyzoites impact the host transcripton in a similar manner as tachyzoites. We found that 3853 differentially expressed genes... -
RNA pol II Dynamics Modulate Co-transcriptional Chromatin Modification, CTD p...
Using pol II mutants in human cells we found that slow transcription repositioned specific co-transcriptionally deposited chromatin modifications H3K36me3 shifted within genes... -
A multi-kingdom genetic barcoding system for target clone isolation
High-throughput sequencing data, including amplicon sequencing, barcode sequencing, single-cell transcriptome assays, RNA-seq, and EM-seq, generated in Ishiguro et al., 2024.... -
Seawater Environmental 16S Raw sequence reads
North Atlantic marine snow (oil associated) microbial sequences -
DMS-MaPseq: A genome-wide or targeted approach for RNA structure probing in vivo
Here we present dimethyl sulfate mutational profiling with sequencing (DMS-MaPseq), which encodes DMS modifications as mismatches using a thermostable group II intron reverse... -
Identification_of_mutational_spectra_in_fission_yeast_DNA_repair_and_chromati...
Cells are constantly under attack by a plethora of DNA damaging agents that arise from both exogenous and endogenous sources. To deal with this threat to cell and organism...