The Netherlands BAG comprises structural biology and enzymology groups at five dutch universities (Utrecht, Groningen, Leiden, Eindhoven and Wageningen) and at the Netherlands Cancer Institute in Amsterdam, with a total of thirteen PIs. The research projects carried out in these groups can be largely classified into two major themes: (i) research on proteins and systems with a strong biomedical relevance and (ii) research concerning the design of new biocatalysts for green chemistry and new-to-nature reactions. Projects deal with prokaryotic and eukaryotic proteins, membrane and soluble proteins, cell surface receptors, and protein-protein, protein-ribonucleotide, protein-drug and enzyme-ligand complexes.