Ready-to-eat (RTE) foods have been considered to be an important reservoir of AR bacteria, which constitutes a direct threat to human health, but this remains largely unexplored. In this study, we analyse the comprehensive profiles of antibiotic resistome by metagenomic approach in ready-to-eat foods and human faeces, which was never reported before. There are 18 ready-to-eat food samples (8 ready-to-eat meat, 7 ready-to-eat vegetables and 3 ready-to-eat fruit) and 6 human faecal samples. The samples were sequenced on the Illumina, NovaSeq PE150.