Membrane-stacking properties of myelin proteins

DOI

Myelin is the multilamellar structure that ensheaths axons and accelerates nervous impulses in the nervous system. The fine structure of myelin remains to be further characterized on the biomolecular scale. There are many myelin proteins that contribute to myelin membrane stacking and are involved in demyelinating diseases. We propose an experiment at the INTER neutron reflectometer, where the properties of these proteins can be investigated on supported stacked lipid bilayers. The proteins and their properties have already been characterized using other methods, but the use of neutrons allow us to probe for biomolecular distances in biomimetic systems. This helps us understand the ultrastructure of myelin from a structural aspect. In this proposal we ask for 4 days of beamtime to carry out measurements involving three abundant myelin proteins in various lipid environments and contrasts.

Identifier
DOI https://doi.org/10.5286/ISIS.E.61003853
Metadata Access https://icatisis.esc.rl.ac.uk/oaipmh/request?verb=GetRecord&metadataPrefix=oai_datacite&identifier=oai:icatisis.esc.rl.ac.uk:inv/61003853
Provenance
Creator Miss Saara Laulumaa; Dr Petri Kursula; Dr Arne Raasakka
Publisher ISIS Neutron and Muon Source
Publication Year 2018
Rights CC-BY Attribution 4.0 International; https://creativecommons.org/licenses/by/4.0/
OpenAccess true
Contact isisdata(at)stfc.ac.uk
Representation
Resource Type Dataset
Discipline Biology; Biomaterials; Engineering Sciences; Life Sciences; Materials Science; Materials Science and Engineering
Temporal Coverage Begin 2015-06-13T00:00:00Z
Temporal Coverage End 2015-06-22T16:50:25Z