Cubosomes as biosensors: A kinetic study of changes to lattice parameter and particle size

DOI

Lipid bicontinuous cubic phases are self-assembled three dimensional lattices, consisting of a single periodic bilayer interwoven by two independent water channels. They can be dispersed in aqueous media and coated with a pluronic to form uniform particles, termed cubosomes. The size of the water channel can be tuned by varying the lipid composition. This proposal characterises changes to cubosomes in response to such variations in lipid composition on multiple length scales, i.e. the lattice parameters and overall particle size. Specifically, it will be the first kinetic study using neutron scattering to monitor the online conversion of cubosome lipid compositions as they form highly curved lipid phases. The findings are essential to fundamentally characterise diagnostic assays, under development within our lab for in vivo applications and commercialisation.

Identifier
DOI https://doi.org/10.5286/ISIS.E.98003381
Metadata Access https://icatisis.esc.rl.ac.uk/oaipmh/request?verb=GetRecord&metadataPrefix=oai_datacite&identifier=oai:icatisis.esc.rl.ac.uk:inv/98003381
Provenance
Creator Dr Hanna Barriga; Dr Derrick Roberts; Professor Molly Stevens; Dr Isaac Pence; Dr Maggie Holme; Dr James Doutch; Miss Valeria Nele
Publisher ISIS Neutron and Muon Source
Publication Year 2021
Rights CC-BY Attribution 4.0 International; https://creativecommons.org/licenses/by/4.0/
OpenAccess true
Contact isisdata(at)stfc.ac.uk
Representation
Resource Type Dataset
Discipline Chemistry; Natural Sciences; Physics
Temporal Coverage Begin 2018-09-18T08:00:00Z
Temporal Coverage End 2018-09-21T12:37:34Z